ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Epigenetics > Sirtuin Inhibitors > SIRTINOL
SIRTINOL
SIRTINOL Basic information
- Product Name:
- SIRTINOL
- Synonyms:
-
- {2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]}-N-(1-phenethyl)benzamide (Sirtinol)
- 2-[(2-HYDROXYNAPHTHALEN-1-YLMETHYLENE)AMINO]-N-(1-PHENETHYL)BENZAMIDE
- SIRTINOL
- SIR TWO INHIBITOR NAPHTHOL
- (E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide
- 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
- 2-{[(2-hydroxynaphthalen-1-yl)Methylidene]aMino}-N-(2-phenylethyl)benzaMide
- Sirtinol - CAS 410536-97-9 - Calbiochem
- CAS:
- 410536-97-9
- MF:
- C26H22N2O2
- MW:
- 394.47
- Product Categories:
-
- Inhibitors
- Inhibitor
- Other Enzyme Inhibitors.
- Other enzyme inhibitors and activators
- Mol File:
- 410536-97-9.mol
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SIRTINOL Chemical Properties
- Melting point:
- 119-120℃
- Boiling point:
- 659.2±50.0 °C(Predicted)
- Density
- 1.16
- storage temp.
- −20°C
- form
- Yellow solid
- pka
- 7.85±0.50(Predicted)
- Water Solubility
- Soluble in water, DMSO and methanol
MSDS
- Language:English Provider:SigmaAldrich
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SIRTINOL Usage And Synthesis
Uses
Sirtinol is a known inhibitor of the NAD+-Dependent Protein Desuccinylase and Demalonylase Sirt5 and exhibits anticancer properties.
Biological Activity
Cell-permeable, selective sirtuin deacetylase inhibitor (IC 50 values are 38, 68 and 131 μ M at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro .
SIRTINOLSupplier
Angel Pharmatech, Ltd. Gold
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ChemeGen(Shanghai) Biotechnology Co.,Ltd. Gold
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J & K SCIENTIFIC LTD.
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VDM Biochemicals
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