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SIRTINOL

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SIRTINOL Basic information

Product Name:
SIRTINOL
Synonyms:
  • {2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]}-N-(1-phenethyl)benzamide (Sirtinol)
  • 2-[(2-HYDROXYNAPHTHALEN-1-YLMETHYLENE)AMINO]-N-(1-PHENETHYL)BENZAMIDE
  • SIRTINOL
  • SIR TWO INHIBITOR NAPHTHOL
  • (E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide
  • 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
  • 2-{[(2-hydroxynaphthalen-1-yl)Methylidene]aMino}-N-(2-phenylethyl)benzaMide
  • Sirtinol - CAS 410536-97-9 - Calbiochem
CAS:
410536-97-9
MF:
C26H22N2O2
MW:
394.47
Product Categories:
  • Inhibitors
  • Inhibitor
  • Other Enzyme Inhibitors.
  • Other enzyme inhibitors and activators
Mol File:
410536-97-9.mol
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SIRTINOL Chemical Properties

Melting point:
119-120℃
Boiling point:
659.2±50.0 °C(Predicted)
Density 
1.16
storage temp. 
−20°C
form 
Yellow solid
pka
7.85±0.50(Predicted)
Water Solubility 
Soluble in water, DMSO and methanol
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Safety Information

WGK Germany 
3

MSDS

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SIRTINOL Usage And Synthesis

Uses

Sirtinol is a known inhibitor of the NAD+-Dependent Protein Desuccinylase and Demalonylase Sirt5 and exhibits anticancer properties.

Biological Activity

Cell-permeable, selective sirtuin deacetylase inhibitor (IC 50 values are 38, 68 and 131 μ M at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro .

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