1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE Chemical Properties

Melting point:

204-206℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

Light Beige to Beige

Stability:

Hygroscopic

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE Usage And Synthesis

Description

1-Methyl-4-imidazoleacetic acid (MIMA) is a stable metabolite of histamine that is produced by the oxidation of the primary metabolite, N-methylhistamine. Urinary levels of MIMA are commonly measured to evaluate histamine secretion, particularly in the context of systemic mastocytosis.

Uses

1-Methyl-4-imidazoleacetic Acid Hydrochloride is a metabolite of histamine (H436500), which is produced by mast cells and involved with the inflammatory response. 1-Methyl-4-imidazoleacetic Acid Hydrochloride can also be used to synthesize N-[1-(9,10-methano-9-anthracenylmethyl)-4-piperidinyl]alkanamides and analogs as dopamine D2 receptor antagonists.

References

[1] KERR J W. IDENTIFICATION OF HISTAMINE METABOLITE 1-METHYL, 4-IMIDAZOLE ACETIC ACID IN HUMAN URINE AND ITS ABSENCE IN STATUS ASTHMATICUS.[J]. BMJ?: British Medical Journal, 1964, 2 5409: 606-608. DOI: 10.1136/bmj.2.5409.606
[2] J. J. VAN DOORMAAL. Tryptase and histamine metabolites as diagnostic indicators of indolent systemic mastocytosis without skin lesions[J]. Allergy, 2012, 67 5: 683-690. DOI: 10.1111/j.1398-9995.2012.02809.x
[3] BYRTHE J.P.R. VOS BSC  Pieter C van V V M  Eveline van der Veer PhD, PHD  André B M M, PHD , et al. Diminished reliability of tryptase as risk indicator of mastocytosis in older overweight subjects[J]. Journal of Allergy and Clinical Immunology, 2015, 135 3: Pages 792-798. DOI: 10.1016/j.jaci.2014.05.047
[4] A. TSOLAKIS. Histidine decarboxylase and urinary methylimidazoleacetic acid in gastric neuroendocrine cells and tumours.[C]//21 47 1. 2015: 13240-13249. DOI: 10.3748/wjg.v21.i47.13240

1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE(35454-39-8)Related Product Information

• METHYL 2-(6-CHLOROIMIDAZO[1,2-A]PYRIDIN-2-YL)ACETATE
• (1H-IMIDAZOL-4-YL)-ACETALDEHYDE
• Imidazole-4-acetic acid
• (1-METHYL-1H-IMIDAZOL-4-YL)-ACETIC ACID
• 2-(3H-imidazol-4-yl)acetic acid
• 4-IMIDAZOLEACETIC ACID HYDROCHLORIDE
• (1-METHYL-1H-IMIDAZOL-4-YL)-ACETALDEHYDE
• 1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE
• Imidazolyl-4-ethanol
• 2-(1,7-diazabicyclo[4.3.0]nona-2,4,6,8-tetraen-8-yl)acetic acid
• BASIONIC(TM) AC 75
• (6-CHLORO-IMIDAZO[1,2-A]PYRIDIN-2-YL)-ACETIC ACID