Hepcidin 1 (Mouse)
Hepcidin 1 (Mouse) Basic information
- Product Name:
- Hepcidin 1 (Mouse)
- Synonyms:
-
- Hepcidin 1 (Mouse)
- L-Threonine, L-α-aspartyl-L-threonyl-L-asparaginyl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-asparaginyl-L-seryl-L-glutaminyl-L-cysteinylglycyl-L-isoleucyl-L-cysteinyl-L-cysteinyl-L-lysyl-, cycli...
- L-Threonine, L-α-aspartyl-L-threonyl-L-asparaginyl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-asparaginyl-L-seryl-L-glutaminyl-L-cysteinylglycyl-L-isoleucyl-L-cysteinyl-L-cysteinyl-L-lysyl-, cyclic (7→23),(10→22),(11→19),(13→14)-tetrakis(disulfide)
- CAS:
- 1676104-75-8
- MF:
- C111H169N31O35S8
- MW:
- 2754.25
- Mol File:
- 1676104-75-8.mol
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Hepcidin 1 (Mouse) Chemical Properties
- Boiling point:
- 2726.8±65.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- Sequence
- H-Asp-Thr-Asn-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Lys-Cys-Cys-Asn-Asn-Ser-Gln-Cys-Gly-Ile-Cys-Cys-Lys-Thr-OH trifluoroacetate salt
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Hepcidin 1 (Mouse) Usage And Synthesis
Uses
Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation[1].
IC 50
MMP-9; cathepsin K
References
[1] Zhao GY, et al. Effects of mouse hepcidin 1 treatment on osteoclast differentiation and intracellular iron concentration. Inflammation. 2015 Apr;38(2):718-27. DOI:10.1007/s10753-014-9982-2
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