3-TRIFLUOROMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE Chemical Properties

Boiling point:

285.7±40.0 °C(Predicted)

Density 

1.545±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

8.21±0.50(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933199090

3-TRIFLUOROMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE Usage And Synthesis

Uses

3-(trifluoromethyl)pyrazole-4-carboxaldehyde is an aldehyde organic compound that can be used as an organic intermediate.

Synthesis

3-(Trifluoromethyl)-1H-pyrazol-4-ylmethanol (54.00 g, 0.325 mol) was used as a raw material and suspended in toluene (2 L). Manganese dioxide (113.00 g, 1.30 mol) and 4?molecular sieve powder (54.00 g) were added to the suspension. The reaction mixture was stirred at reflux for 5.5 hours under nitrogen protection, assembled with a Dean-Stark splitter. Upon completion of the reaction, the reaction mixture was filtered while hot, the filter cake was collected and cooled to room temperature. The filter cake was washed with a 1:1 mixture of dichloromethane and methanol (3 x 500 mL). All the filtrates were combined and the solvent was removed by concentration under reduced pressure to afford the target product 3-(trifluoromethyl)pyrazole-4-carbaldehyde (54.00 g, 0.329 mol, 100% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.72 (s, 1H), 9.91 (s, 1H).

References

[1] Patent: US2009/131455, 2009, A1. Location in patent: Page/Page column 8
[2] Patent: WO2008/3452, 2008, A1. Location in patent: Page/Page column 53

3-TRIFLUOROMETHYL-1H-PYRAZOLE-4-CARBALDEHYDE(1001020-14-9)Related Product Information

• 1-Methyl-1H-pyrazole-4-boronic acid
• 3-TRIFLUOROMETHYL-2-FORMYLPYRIDINE
• 3-(Trifluoromethyl)-6,7,8,9-tetrahydro-5H-carbazole
• methyl 3-trifluoro-2-pyridinecarboxylate
• 3-(Trifluoromethyl)pyrazole