(±)-HIP-A
(±)-HIP-A Basic information
- Product Name:
- (±)-HIP-A
- Synonyms:
-
- 3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-4-CARBOXYLIC ACID
- HIP-A
- 2H-Pyrrolo[3,4-d]isoxazole-4-carboxylic acid, hexahydro-3-oxo-, (3aR,4S,6aR)-rel-
- (+/-)-HIP-A
- (±) HIP A,(±)HIPA
- CAS:
- 227619-64-9
- MF:
- C6H8N2O4
- MW:
- 172.14
- Product Categories:
-
- Glutamate receptor
- Mol File:
- 227619-64-9.mol
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(±)-HIP-A Chemical Properties
- storage temp.
- Store at +4°C
- solubility
- Soluble to 10 mM in sterile water
- form
- Powder
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(±)-HIP-A Usage And Synthesis
Uses
(+/-)-HIP-A is anew AMPA-kainate receptor agonist.
Biological Activity
Potent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [ 3 H]D-aspartate release (IC 50 = 1.6 μ M) rather than [ 3 H]L-glutamate uptake (IC 50 = 18 μ M). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC 50 values are 43 and 8 μ M respectively).
(±)-HIP-ASupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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BOC Sciences
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