o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1) Basic information
- Product Name:
- o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
- Synonyms:
-
- o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)
- Cloperastine fendizoate
- Levocloperastine Fendizoate
- Cloperastine Febdizoate
- 1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine Fendizoate
- Levocloperastine Fendizoate Racemic Impurity
- 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,2-(4-hydroxy-3-phenylbenzoyl)benzoic acid
- Cloperastine fendiz
- CAS:
- 85187-37-7
- MF:
- C40H38ClNO5
- MW:
- 648.2
- EINECS:
- 286-126-9
- Mol File:
- 85187-37-7.mol
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1) Chemical Properties
- Melting point:
- 185-187°C
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChIKey
- PXZFKAKWSHBDCP-UHFFFAOYSA-N
- SMILES
- C(C1C=CC=CC=1)(C1C=CC(Cl)=CC=1)OCCN1CCCCC1.OC1=CC=C(C(C2C=CC=CC=2C(=O)O)=O)C=C1C1C=CC=CC=1
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1) Usage And Synthesis
Uses
Cloperastine fendizoate is used in the treatment of chronic non-productive cough. Antitussive. it is the salt of Cloperastine (CAS:3703-76-2)
Definition
ChEBI: Cloperastine fendizoate is a N-oxyethylpiperidine. It is functionally related to a benzoate.
in vivo
In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width[1]. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively[2].
o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1)Supplier
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