Basic information Safety Supplier Related

phenglutarimide

Basic information Safety Supplier Related

phenglutarimide Basic information

Product Name:
phenglutarimide
Synonyms:
  • GLUTARIMIDE,2-((2-DIETHYLAMINO)ETHYL)-2-PHENYL-
  • ATURBANE
  • 3-[2-(Diethylamino)ethyl]-3-phenyl-2,6-piperidinedione
  • Aturban
  • Ciba-10870
  • Phenglutarimid
  • 1674-96-0 (Hydrochloride)
  • 2-(2-(Diethylamino)ethyl)-2-phenylglutarimide
CAS:
1156-05-4
MF:
C17H24N2O2
MW:
288.389
EINECS:
2145878
Mol File:
1156-05-4.mol
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phenglutarimide Chemical Properties

Melting point:
125-127°
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phenglutarimide Usage And Synthesis

Originator

Ciba 10870, Ciba Pharmaceutical

Definition

ChEBI: Phenglutarimide is a member of piperidines.

Manufacturing Process

350 parts by weight of the potassium salt of 2-phenyl-2-(βdiethylaminoethyl)-pentane-1,5-diacid mononitrile are dissolved with heating in 700 parts by volume of glacial acetic acid, 850 parts by volume of acetic anhydride are added, and then 250 parts by volume of concentrated sulfuric acid introduced portionwise. The temperature of the reaction mixture in this operation rises to 120-130°C. When the reaction subsides, the whole is finally maintained for a further 15 min on the boiling water bath. The solvent is removed on the water bath under reduced pressure, the residue poured onto ice and caustic soda solution, and the whole extracted with chloroform. The chloroform solution washed with water, dried over potassium carbonate and the solvent evaporated. The crystalline residue, consisting of 3-phenyl-3-(βdiethylaminoethyl)-2,6-dioxopiperidine. After recrystallization from a mixture of ethyl acetate and ligroin, melts at 118-120°C.
The hydrochloride (produced by dissolving the base in ethyl acetate and adding an equivalent quantity of hydrochloric acid gas dissolved in ethylacetate) melts, after recrystallization from a mixture of methyl alcohol and ethyl acetate, at 168-172°C.

Therapeutic Function

Anticholinergic, Antiparkinsonian

phenglutarimideSupplier

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Jinan Ruisi Pharmaceutical Technology Co., LTD
Tel
0531-69900633 18340090523
Email
changyuan20@163.com
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-81148696 +86-15536356810
Email
1022@dideu.com
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
15229059051
Email
1027@dideu.com
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