azidamfenicol Chemical Properties

Melting point:

107°

alpha 

D20 -20° (c = 1.6 in ethyl acetate)

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

Ethyl Acetate (Slightly, Sonicated), Methanol (Slightly)

form 

Solid

color 

White to Off-White

azidamfenicol Usage And Synthesis

Originator

Berlicetin-,Chauvin

Uses

Azidamfenicol is a semi-synthetic chloramphenicol in which the nitro moiety is replaced with a methylsulphone and the dichloroacetamide is replaced with azidoacetamide, first synthesised at Bayer in 1959. Azidamfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Azidamfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Azidamfenicol has received little research attention with only a few literature citations.

Definition

ChEBI: Azidamfenicol is an organonitrogen compound and an organooxygen compound. It is functionally related to an alpha-amino acid.

Manufacturing Process

21.2 g of D-(-)-threo-1-p-nitrophenyl-2-aminopropane-1,3-diol are stirred with 10 g of azidoacetonitrile (B.P. 68°C/25 mm) in a mixture of 125 ml of methanol and 125 ml of water at 30-40°C for a few days. The mixture is filtered off from a little undissolved base and the solvent is distilled in vacuo. The residue is treated with a little normal hydrochloric acid until acid to Congo red and extracted with ethylacetate. By evaporating the solvent and recrystallizing the residue from ethylene chloride is obtained D-(-)-threo-1-pnitrophenyl- 2-azidoacetylamino-propane-1,3-diol, M.P. 107°C.

Therapeutic Function

Antibiotic

azidamfenicol(13838-08-9)Related Product Information

• Ethyl acetate
• Chloramphenicol
• azidamfenicol
• 2-Amino-1-(4-nitrophenyl)-1,3-propanediol