plafibride
plafibride Basic information
- Product Name:
- plafibride
- Synonyms:
-
- 1-[2-(4-Chlorophenoxy)-2-methylpropionyl]-3-(morpholinomethyl)urea
- 2-(4-Chlorophenoxy)-2-methyl-N-[[(4-morpholinylmethyl)amino]carbonyl]propanamide
- Idonor
- ITA-104
- 1-(2-(p-Chlorophenoxy)-2-methylpropionyl)-3-(morpholinomethyl)urea
- Brn 0569805
- Einecs 264-121-2
- N-(2-(4-Chlorophenoxy)isobutyryl)-N-morpholinomethylurea
- CAS:
- 63394-05-8
- MF:
- C16H22ClN3O4
- MW:
- 355.82
- EINECS:
- 2641212
- Mol File:
- 63394-05-8.mol
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plafibride Chemical Properties
- Melting point:
- 100-102°
- Density
- 1.3022 (rough estimate)
- refractive index
- 1.6800 (estimate)
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plafibride Usage And Synthesis
Uses
Plafibride (ITA 104) is an orally active hypolipemic, platelet aggregation inhibitor[1][2].
Definition
ChEBI: Plafibride is an aromatic ether.
in vivo
Plafibride (100 mg/kg, p.o.) shows marked platelet anti-aggregant activity[1].
Plafibride has low toxicity, with LD50s of about 4000 mg/kg (p.o.) in rat, mouse and hamster[2].
| Animal Model: | Rabbit[1] |
| Dosage: | 100 mg/kg |
| Administration: | Oral administration (p.o.) |
| Result: | Induced platelet aggregation. |
References
[1] L Bruseghini, et al. Platelet antiaggregant activity of plafibride ex vivo in rat, dog and rabbit. Arzneimittelforschung. 1981;31(10a):1790-5. PMID:6797443
[2] J Zapatero, et al. Toxicological studies of plafibride. Part 1: Acute toxicity and its determination after several administrations of plafibride. Arzneimittelforschung. 1981;31(10a):1816-9. PMID:7198458