piprofurol
piprofurol Basic information
- Product Name:
- piprofurol
- Synonyms:
-
- piprofurol
- 4,7-Dimethoxy-α-[2-(4-hydroxyphenyl)ethyl]-6-[2-(1-piperidinyl)ethoxy]-5-benzofuranmethanol
- α-(p-Hydroxyphenethyl)-4,7-dimethoxy-6-[(2-piperidinoethyl)oxy]-5-benzofuranmethanol
- Piprofurolum
- 5-Benzofuranmethanol, α-[2-(4-hydroxyphenyl)ethyl]-4,7-dimethoxy-6-[2-(1-piperidinyl)ethoxy]-
- CAS:
- 40680-87-3
- MF:
- C26H33NO6
- MW:
- 455.548
- EINECS:
- 2550356
- Mol File:
- 40680-87-3.mol
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piprofurol Chemical Properties
- Boiling point:
- 640.7±55.0 °C(Predicted)
- Density
- 1.214±0.06 g/cm3(Predicted)
- pka
- 10.05±0.15(Predicted)
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piprofurol Usage And Synthesis
Uses
Piprofurol is a calcium channel inhibitor. Piprofurol inhibits the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta in a concentration-dependent manner and relaxes the K+-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM[1].
References
[1] Pourrias B, et al. Calcium blocking properties of piprofurol. Arch Int Pharmacodyn Ther. 1985;274(2):223-239. PMID:4026458
piprofurolSupplier
TargetMol Chemicals Inc.
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TargetMol Chemicals Inc.
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TargetMol Chemicals Inc.
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