laudanosine Chemical Properties

Melting point:

89°

alpha 

D16 +106° (c = 1.6 in 97% alc); D16 +130° (chloroform); D22 +52.2 ±1.3° (chloroform); D20 +82.5° (ethanol)

Boiling point:

490.07°C (rough estimate)

Density 

1.1729 (rough estimate)

refractive index 

1.5614 (estimate)

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated)

form 

White to Pale Beige

pka

7.80±0.40(Predicted)

laudanosine Usage And Synthesis

Uses

Laudanosine is a metabolite of the neuromuscular-blocking drugs Atracurium (A794500) and Cisatracurium (C496700) with potentially toxic systemic effects. It crosses the blood-brain barrier and may cause excitement and seizure activity.

Definition

ChEBI: Laudanosine is a member of isoquinolines.

Purification Methods

Crystallise these from EtOH. The (±)-picrate crystallises from EtOH with m 177-178o. The (-)-isomer has m 83-85o and

laudanosine (2688-77-9)Related Product Information

• Cisatracurium Besilate EP Impurity W Iodide (Mixture of Diastereomers)
• Cisatracurium Besilate EP Impurity N and O Iodide (Mixture of Diastereomers)
• Atracurium EP Impurity D Iodide (Mixture of Diastereomers)
• Atracurium Impurity 1
• (R-trans, R-trans)-AtracuriuM Besylate
• PHENYL P-TOLYL SULFONE
• Atracurium Impurity 27 Besylate
• Atracurium EP Impurity K Iodide (Mixture of Diastereomers)
• Atracurium Impurity 15
• Atracurium Impurity 19
• AtracuriuM IMpurity A1 (trans-Monoquatenary)
• Atracurium Impurity 34 Iodide
• Cisatracurium Besilate EP Impurity T Iodide
• Atracurium Impurity 30 Besylate
• Atracurium Impurity 12 Iodide (Mixture of Diastereomers)
• Atracurium Impurity 24
• 1-(3,4-dimethoxy-benzyl)-7,8-dimethoxy-1,2,3,4-tetrahydro-isoquinoline
• Atracurium Impurity 37 Besylate