N-(4-fluoro-3-nitrophenyl)acetamide Chemical Properties

Melting point:

138.5 °C

Boiling point:

385.9±32.0 °C(Predicted)

Density 

1.429±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

pka

13.18±0.70(Predicted)

color 

Yellow-brown

EPA Substance Registry System

Acetamide, N-(4-fluoro-3-nitrophenyl)- (351-32-6)

Safety Information

TSCA 

TSCA listed

HS Code 

2924297099

N-(4-fluoro-3-nitrophenyl)acetamide Usage And Synthesis

Synthesis

Step B. 4-Fluoro-3-nitroaniline (5.0 g, 32.0 mmol) and triethylamine (TEA, 6.7 mL, 48.0 mmol) were dissolved in 50 mL of dichloromethane (DCM) at 0 °C. Subsequently, acetyl chloride (2.75 mL, 38.4 mmol) was slowly added dropwise, and after completion of the dropwise addition the reaction mixture was warmed to room temperature and stirred overnight. Upon completion of the reaction, the organic layer was washed sequentially with 5% aqueous potassium bisulfate (KHSO4), saturated aqueous sodium bicarbonate (NaHCO3) and brine, and then dried over anhydrous magnesium sulfate (MgSO4). By concentrating the organic phase and crystallizing from DCM, 5.3 g of N-(4-fluoro-3-nitrophenyl)acetamide was obtained in 84% yield. The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-D): δ 2.04 (s, 3H), 7.51 (dd, J = 11.23,9.08 Hz, 1H), 7.80 (dd, J = 9.08,4.00,2.93 Hz, 1H), 8.47 (dd, J = 7.03,2.73 Hz, 1H), 10.38 (s 1H).

References

[1] Patent: WO2005/72741, 2005, A1. Location in patent: Page/Page column 26
[2] Patent: WO2006/33630, 2006, A1. Location in patent: Page/Page column 34; 35
[3] Patent: WO2005/30733, 2005, A1. Location in patent: Page/Page column 67; 140
[4] Patent: WO2006/33629, 2006, A1. Location in patent: Page/Page column 17
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 20, p. 5545 - 5549

N-(4-fluoro-3-nitrophenyl)acetamide(351-32-6)Related Product Information

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