BAY R3401
BAY R3401 Basic information
- Product Name:
- BAY R3401
- Synonyms:
-
- 4-(2-Chlorophenyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylic acid isopropyl ester
- BAY R3401 >=98% (HPLC), solid
- Furo[3,4-b]pyridine-3-carboxylic acid, 4-(2-chlorophenyl)-1-ethyl-1,4,5,7-tetrahydro-2-methyl-5-oxo-, 1-methylethyl ester
- CAS:
- 100276-03-7
- MF:
- C20H22ClNO4
- MW:
- 375.85
- Mol File:
- 100276-03-7.mol
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BAY R3401 Chemical Properties
- Melting point:
- 110-112 °C
- Boiling point:
- 512.6±50.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL
- form
- solid
- pka
- -0.68±0.70(Predicted)
- color
- white
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BAY R3401 Usage And Synthesis
Uses
BAY R3401 is an orally active glycogen phosphorylase inhibitor that can achieve irreversible and non-selective inhibition of hepatic glycogenolysis. BAY R3401 inhibits glycogenolysis in liver cells, with IC50 values of 27.06 and 52.83 μM in HL-7702 and HepG2 cells, respectively. BAY R3401 can be used for the research of type 2 diabetes[1].
References
[1] Zhang L, et al. Design, Synthesis, and Biological Application of Novel Photoaffinity Probes of Dihydropyridine Derivatives, BAY R3401. Molecules. 2019 Jun 28;24(13):2394. DOI:10.3390/molecules24132394