Etoxadrol
Etoxadrol Basic information
- Product Name:
- Etoxadrol
- Synonyms:
-
- Etoxadrol
- (S)-2-[(2S)-2-Ethyl-2α-phenyl-1,3-dioxolan-4β-yl]piperidine
- Nsc288020
- Piperidine, 2-(2-ethyl-2-phenyl-1,3-dioxolan-4-yl)-
- Piperidine, 2-(2-ethyl-2-phenyl-1,3-dioxolan-4-yl)-, (+)-
- Piperidine, 2-[(2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl]-, (2S)-
- CAS:
- 28189-85-7
- MF:
- C16H23NO2
- MW:
- 261.36
- Mol File:
- 28189-85-7.mol
Etoxadrol Chemical Properties
- Boiling point:
- 404.61°C (rough estimate)
- Density
- 1.0086 (rough estimate)
- refractive index
- 1.5500 (estimate)
- pka
- 9.57±0.10(Predicted)
- Water Solubility
- 0.65g/L(20 ºC)
Etoxadrol Usage And Synthesis
Uses
Etoxadrol (CL-1848C) is a potent, high-affinity N-methyl-D-aspartic acid (NMDA) antagonist. Etoxadrol is used in the anaesthetic and anaesthesia research community to suppress or relieve pain[1].
in vivo
Etoxadrol (CL-1848C) (100.0 mg/kg; i.h.; once) produces marked stimulation and ataxia in mice[2].
Etoxadrol (0-20 mg/kg; i.v.; once) decreases brain monoamine concentrations after 4 h injection[3].
| Animal Model: | Carworth-Farm (Upjohn) male mice weighing 18 to 20 gm[2] |
| Dosage: | 100.0 mg/kg |
| Administration: | Subcutaneous injection, 30 min |
| Result: | Produced marked stimulation and ataxia. |
| Animal Model: | Male CFE rats weighing 110-175 g (average 130 g)[3] |
| Dosage: | 5, 10, and 20 mg/kg |
| Administration: | Intravenous injection, once |
| Result: | Significantly lowered brain serotonin, DA (dopamine), and NE (norepinephrine) concentrations at 4 h. |
References
[1] A Thurkauf, et al. Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. J Med Chem. 1988 Dec;31(12):2257-63. DOI:10.1021/jm00120a004
[2] A H Tang, et al. Analgetic activities of etoxadrol in the rhesus monkey and in mice. Anesth Analg. 1973 Jul-Aug;52(4):577-83. PMID:4197876
[3] Y F Sung, et al. Effects of intravenous anesthetics on brain monoamines in the rat. Anesthesiology. 1973 Nov;39(5):478-87. DOI:10.1097/00000542-197311000-00004
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