1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Chemical Properties

Boiling point:

478.8±28.0 °C(Predicted)

Density 

1.083±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

7.99±0.50(Predicted)

1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Usage And Synthesis

Uses

ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.

Definition

ChEBI: 1-(2-naphthalenyl)-3-[(phenylmethyl)-propan-2-ylamino]-1-propanone is a member of naphthalenes.

IC 50

JAK3: 7.1 (pIC₅₀); JAK1: 4.4 (pIC₅₀); EGF-R: 5.6 (pIC₅₀); Lck: 5.0 (pIC₅₀); CDK4: 5.0 (pIC₅₀); TGM2: 10 nM (IC₅₀)

References

[1] Brown GR, et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. DOI:10.1016/s0960-894x(00)00051-2
[2] Lai TS, et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78. DOI:10.1016/j.chembiol.2008.07.015
[3] Zhang Z, et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197. DOI:10.3892/ol.2017.5861

1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-(273727-89-2)Related Product Information

• Naftifine Impurity 8
• ZM 39923 HCl
• 1-Propanone, 3-[methyl(phenylmethyl)amino]-1-phenyl-
• 3-[Methyl(1-naphthalenylmethyl)amino]-1-phenyl-1-Propanone
• ZM 39923 HYDROCHLORIDE
• 1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-