(11b)-11,17,21-trihydroxy-3,20-dioxo-Pregn-4-en-18-al
(11b)-11,17,21-trihydroxy-3,20-dioxo-Pregn-4-en-18-al Basic information
- Product Name:
- (11b)-11,17,21-trihydroxy-3,20-dioxo-Pregn-4-en-18-al
- Synonyms:
-
- (11b)-11,17,21-trihydroxy-3,20-dioxo-Pregn-4-en-18-al
- 18-Oxocortisol
- Pregn-4-en-18-al, 11,17,21-trihydroxy-3,20-dioxo-, (11β)-
- CAS:
- 2410-60-8
- MF:
- C21H28O6
- MW:
- 376.44
- Mol File:
- 2410-60-8.mol
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(11b)-11,17,21-trihydroxy-3,20-dioxo-Pregn-4-en-18-al Chemical Properties
- Melting point:
- 208.5-209.5 °C
- Boiling point:
- 606.4±55.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- form
- Solid
- pka
- 11.85±0.70(Predicted)
- color
- White to Off-White
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(11b)-11,17,21-trihydroxy-3,20-dioxo-Pregn-4-en-18-al Usage And Synthesis
Uses
18-Oxocortisol is used in biological studies on anti-malarial drug artesunate restoring metabolic changes in experimental allergic astham.
in vivo
Administration of 18-oxocortisol to rats induces a mineralocorticoid-type hypertension with hypokalemia, cardiac and renal enlargement and cardiovascular lesions. Administration of 18-oxocortisol to sheep also causes a rapid increase in blood pressure. However, the doses required for increasing blood pressure are high[3].
(11b)-11,17,21-trihydroxy-3,20-dioxo-Pregn-4-en-18-alSupplier
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