Medermycin
Medermycin Basic information
- Product Name:
- Medermycin
- Synonyms:
-
- Medermycin
- [3aS,(-)]-3,3aβ,5,11bβ-Tetrahydro-7-hydroxy-5β-methyl-8-[3-(dimethylamino)-2,3,6-trideoxy-L-arabino-hexopyranosyl]-2H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11-trione
- Lactoquinomycin
- 2H-Furo[3,2-b]naphtho[2,3-d]pyran-2,6,11-trione, 3,3a,5,11b-tetrahydro-7-hydroxy-5-methyl-8-[2,3,6-trideoxy-3-(dimethylamino)-β-D-arabino-hexopyranosyl]-, (3aR,5R,11bR)-
- CAS:
- 60227-09-0
- MF:
- C24H27NO8
- MW:
- 457.47
- Mol File:
- 60227-09-0.mol
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Medermycin Usage And Synthesis
Uses
Lactoquinomycin A is a quinone antibiotic. Lactoquinomycin A has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.02, 0.006, 0.008, 0.033, 0.013 and 0.03, respectively[1].
Definition
ChEBI: Medermycin is a benzoisochromanequinone and a member of p-quinones.
References
[1] Beomkoo Chung, et al. Antibacterial Activity and Mode of Action of Lactoquinomycin A from Streptomyces bacillaris. Mar Drugs. 2020 Dec 24;19(1):7.