PD 142893 Chemical Properties

Sequence

Ac-{d-Dip}-Leu-Asp-Ile-Ile-Trp

PD 142893 Usage And Synthesis

Description

PD 142893 is a functional antagonist of endothelin-stimulated vasoconstriction.

Uses

PD 142893 is a endothelin-B receptor antagonist[1].

References

[1] Cody WL, et al. Structure-activity relationships of the potent combined endothelin-A/endothelin-B receptor antagonist Ac-DDip16-Leu-Asp-Ile-Ile-Trp21: development of endothelin-B receptor selective antagonists. J Med Chem. 1995;38(15):2809-2819. DOI:10.1021/jm00015a003