LY 278584 Chemical Properties

Boiling point:

522.1±40.0 °C(Predicted)

Density 

1.36±0.1 g/cm3(Predicted)

form 

Solid

pka

12.34±0.20(Predicted)

LY 278584 Usage And Synthesis

Uses

LY 278584 is a potent, highly selective 5-HT3 receptor antagonist with a Ki of 1.62 nM. LY 278584 has no activity on 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, or 5-HT2 receptors[1].

Definition

ChEBI: 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-3-indazolecarboxamide is an aromatic amide and a member of indazoles.

IC 50

5-HT₃ Receptor: 1.62 nM (Ki)

References

[1] D W Robertson, et al. Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors. J Med Chem. 1990 Dec;33(12):3176-81. DOI:10.1021/jm00174a013