S 14671
S 14671 Basic information
- Product Name:
- S 14671
- Synonyms:
-
- S 14671
- N-[2-[4-(7-Methoxynaphthalen-1-yl)piperazin-1-yl]ethyl]-2-thiophenecarboxamide
- N-[2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl]thiophene-2-carboxamide
- 2-Thiophenecarboxamide, N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]-
- S14671,S 14671
- CAS:
- 135722-27-9
- MF:
- C22H25N3O2S
- MW:
- 395.52
- Mol File:
- 135722-27-9.mol
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S 14671 Chemical Properties
- Boiling point:
- 646.7±55.0 °C(Predicted)
- Density
- 1.225±0.06 g/cm3(Predicted)
- pka
- 14.51±0.46(Predicted)
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S 14671 Usage And Synthesis
Description
S-14671 is a 5-HT1A receptor agonist (pKi = 9.3) with high efficacy and exceptional in vivo potency, and also as a 5-HT2A and 5-HT2C receptor antagonist (both are pKi = 7.8). It displays only low and non-significant affinity for 5-HT1B and 5-HT3 sites.
Uses
S-14671 is a high-affinity 5-HT1A agonist (pKi=9.3). S-14671 can be used for research on neurological diseases, such as anti-anxiety, anti-depression, etc[1].
IC 50
5-HT1A Receptor: 9.3 (pKi)
References
[1] Millan MJ, et al. S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency. Eur J Pharmacol. 1991 Oct 15;203(2):319-22. DOI:10.1016/0014-2999(91)90734-8