BIBN 99
BIBN 99 Basic information
- Product Name:
- BIBN 99
- Synonyms:
-
- BIBN 99
- N-[3-[1-[2-(8-chloro-6-oxo-5~{H}-pyrido[2,3-b][1,4]benzodiazepin-11-yl)-2-oxoethyl]piperidin-4-yl]propyl]-N-ethyl-2,2-dimethylpentanamide
- Pentanamide, N-[3-[1-[2-(8-chloro-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)-2-oxoethyl]-4-piperidinyl]propyl]-N-ethyl-2,2-dimethyl-
- CAS:
- 145301-48-0
- MF:
- C31H42ClN5O3
- MW:
- 568.15
- Mol File:
- 145301-48-0.mol
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BIBN 99 Usage And Synthesis
Description
Bibn 99 is a lipophilic and selective muscarinic M2 receptor antagonist with applications to cognitive performance and Alzheimer's Disease.
Uses
BIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury[1][2].
References
[1] Doods H, et al. Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist. Eur J Pharmacol. 1993 Sep 21;242(1):23-30. DOI:10.1016/0014-2999(93)90005-3
[2] Pike BR, et al. Post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats. Brain Res. 1995 Jul 17;686(1):37-43. DOI:10.1016/0006-8993(95)00448-y