Ro 14-9578
Ro 14-9578 Basic information
- Product Name:
- Ro 14-9578
- Synonyms:
-
- Ro 14-9578
- 6,7-Dihydro-6-methyl-2-oxo-2H-[1,3]benzodioxolo[5,6-a]quinolizine-3-carboxylic acid
- CAS:
- 100891-41-6
- MW:
- 0
- Mol File:
- 100891-41-6.mol
More
Less
Ro 14-9578 Usage And Synthesis
Description
Ro 14-9578 is a tricyclic quinolone antibacterial agent.
Uses
Ro 14-9578 is a tricyclic quinolone analog with antibacterial activity. Ro 14-9578 inhibits DNA biosynthesis (IC50=117 μM) and DNA supercoiling (IC50=66.8 μM) in Escherichia coli. Furthermore, Ro 14-9578 exhibits inhibitory effects against various Gram-negative bacteria and Staphylococcus aureus[1].
References
[1] Georgopapadakou N H, et al. Monocyclic and tricyclic analogs of quinolones: mechanism of action[J]. Antimicrobial agents and chemotherapy, 1987, 31(4): 614-616. DOI:10.1128/AAC.31.4.614