okicenone
okicenone Basic information
- Product Name:
- okicenone
- Synonyms:
-
- okicenone
- 3,4-Dihydro-4,6,9-trihydroxy-8-methylanthracen-1(2H)-one
- 1(2H)-Anthracenone, 3,4-dihydro-4,6,9-trihydroxy-8-methyl-
- CAS:
- 137018-54-3
- MF:
- C15H14O4
- MW:
- 258.27
- Mol File:
- 137018-54-3.mol
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okicenone Usage And Synthesis
Description
Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation.
Uses
Okicenone is a Hu protein R (HuR) inhibitor. Okicenone inhibits HuR oligomerization, interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation[1].
References
[1] Meisner NC, et al. Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR. Nat Chem Biol. 2007 Aug;3(8):508-15. DOI:10.1038/nchembio.2007.14
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