Ro 23-7014
Ro 23-7014 Basic information
- Product Name:
- Ro 23-7014
- Synonyms:
-
- Ro 23-7014
- L-Phenylalaninamide, N-acetyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-O-sulfo-L-threonyl-Nα-methyl- (9CI)
- CAS:
- 113714-78-6
- MF:
- C48H63N9O16S4
- MW:
- 1150.32452
- Mol File:
- 113714-78-6.mol
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Ro 23-7014 Chemical Properties
- Density
- 1.424±0.06 g/cm3(Predicted)
- pka
- -4.16±0.18(Predicted)
- Sequence
- Ac-{Tyr(SO3H)}-Met-Gly-Trp-Met-{Thr(SO3H)}-{N-methyl-Phe}-NH2
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Ro 23-7014 Usage And Synthesis
Description
Ro 23-7014 is a new thiazepinone Ca2+ channel antagonist that has high affinity for peripheral (Type A) receptors.
Uses
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7)[1].
References
[1] Danho W, et al. Synthesis and biological activity of novel, potent and long-acting analogs of AC-CCK-7 with high affinity for peripheral (type A) receptors. Pept Res. 1991 Mar-Apr;4(2):59-65. PMID:1815779