KF 14124
KF 14124 Basic information
- Product Name:
- KF 14124
- Synonyms:
-
- KF 14124
- Dptpp-2-ismn
- L-Iditol, 1,4:3,6-dianhydro-2-deoxy-2-[4-[3-(phenylthio)propyl]-1-piperazinyl]-, 5-nitrate
- CAS:
- 134186-26-8
- MF:
- C19H27N3O5S
- MW:
- 409.49978
- Mol File:
- 134186-26-8.mol
KF 14124 Chemical Properties
- Boiling point:
- 556.3±50.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- pka
- 7.55±0.10(Predicted)
KF 14124 Usage And Synthesis
Description
KF 14124 showed potent anti-ischemic activity in a lysine-vasopressin-induced angina pectoris model (rats).
Uses
KF-14124, an orally active organic nitrate, a long-acting vasodilator with highly selective venous dilating action. KF-14124 is used in the study for angina pectoris. KF-14124 shows good oral inhibition of lysine-vasopressin induced coronary vasospasm with a potency[1][2].
in vivo
KF-14124 (0.3 mg/kg intraduodenal administration (i.d.)) tends to decrease left ventricular end-diastolic pressure (LVEDP) in a Propranolol-induced heart failure model (dogs) and shows a potent protective effect against reperfusion arrhythmia in rats[1].
References
[1] 1,4:3,6-Dianhydrohexitol nitrate derivatives. I. Synthesis and antianginal activity of alkylpiperazine derivatives. Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1091-9. DOI:10.1248/cpb.41.1091
[2] Giorgio Bertolini, et al. Overview: Recent Advances in Organic Nitrates. Current Opinion on Therapeutic Patents Volume 3, 1993 - Issue 10.