EMODICACID Chemical Properties

Melting point:

345-350 °C (decomp)(Solv: acetic acid (64-19-7))

Boiling point:

703.8±60.0 °C(Predicted)

Density 

1.798±0.06 g/cm3(Predicted)

pka

3.10±0.20(Predicted)

LogP

2.941 (est)

EMODICACID Usage And Synthesis

Uses

Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1].

Definition

ChEBI: Emodicacid is a member of anthracenes.

References

[1] Amira A Abdellatef, et al. Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus. J Nat Med. 2021 Sep;75(4):840-853. DOI:10.1007/s11418-021-01526-w

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