Basic information Safety Supplier Related

A[5']P5[5']A SODIUM SALT

Basic information Safety Supplier Related

A[5']P5[5']A SODIUM SALT Basic information

Product Name:
A[5']P5[5']A SODIUM SALT
Synonyms:
  • A[5']P5[5']A SODIUM SALT
  • P1,P5-DI(ADENOSINE-5') PENTAPHOSPHATE SODIUM SALT
  • Adenosine 5'-(hexahydrogen pentaphosphate), 5'->5'-ester with adenosine, pentasodium salt
  • P1,P5-DI(ADENOSINE-5') PENTAPHOSPHATESOD IUM
  • P1,P5-di(adenosine-5')pentaphosphate pentasodium salt 5H2O
  • Adenosine-5'-pentaphosphateε-5'-adenosyl α,β,γ,δ,ε-pentasodium salt
  • A(5′)P5(5′)A
  • Diadenosine pentaphosphate pentasodium salt
CAS:
4097-04-5
MF:
C20H24N10Na5O22P5
MW:
1026.28
EINECS:
223-852-7
Mol File:
4097-04-5.mol
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A[5']P5[5']A SODIUM SALT Chemical Properties

storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white to white with yellow cast
BRN 
4949216
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Safety Information

WGK Germany 
3
10-21

MSDS

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A[5']P5[5']A SODIUM SALT Usage And Synthesis

Uses

P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt has been used as:
  • an adenylate kinase (AK) inhibitor in: sarcoma osteogenic (Saos-2) cells
  • mitochondrial lysates during ATP synthesis
  • tetramethylrhodamine methyl ester (TMRM) based membrane potential assay
  • chromoplasts

General Description

P1,P5-Di(adenosine-5′) pentaphosphate (Ap5A) is a diadenosine polyphosphate, which has a tail-to-tail dimer structure. Ap5A is synthesized in a twostep process involving the formation of adenosine 5′-tetraphosphate (P4A) from the ATP and trimeta-phosphate (P3). In the second step, P4A is converted to Ap5A. The synthesis of Ap5A requires a pH optimum in the range of 7.5 to 8.5 and is modulated by metal ions.

Biochem/physiol Actions

A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.

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