1,3-BENZOTHIAZOL-2-YLMETHYLAMINE HYDROCHLORIDE Chemical Properties

Melting point:

125-127℃

Boiling point:

282℃

Density 

1.300

Flash point:

124℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

powder

pka

7.34±0.29(Predicted)

Appearance

Yellow to orange Solid

1,3-BENZOTHIAZOL-2-YLMETHYLAMINE HYDROCHLORIDE Usage And Synthesis

Synthesis

Benzothiazole-2-carbaldehyde oxime (1.78 g, 10 mmol) was mixed with zinc powder (0.98 g, 15 mmol) and ammonium formate (1.26 g, 20 mmol) in 100 mL of methanol in a round bottom flask. The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, the mixture was poured into water and extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and purified by column chromatography to afford 1,3-benzothiazole-2-methylamine as solid powder in 93% yield.

References

[1] Patent: CN108530438, 2018, A. Location in patent: Paragraph 0022; 0024

1,3-BENZOTHIAZOL-2-YLMETHYLAMINE HYDROCHLORIDE(42182-65-0)Related Product Information

• 1,3-BENZOTHIAZOL-2-YLMETHYLAMINE HYDROCHLORIDE,1,3-Benzothiazol-2-ylmethylamine hydrochloride, 97+%
• 2-Benzothiazolamine