Basic information Safety Supplier Related

11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

Basic information Safety Supplier Related

11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA Basic information

Product Name:
11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
Synonyms:
  • 9ALPHA, 11BETA-DIHYDROXY-15-OXO-PROST-5Z-EN-1-OIC ACID
  • 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
  • 11β-13,14-dihydro-15-keto Prostaglandin F2α
  • VKTIONYPMSCHQI-KGILNJEGSA-N
  • 11β-13,14-dihydro-15-keto Prostaglandin F2α
CAS:
107615-77-0
MF:
C20H34O5
MW:
354.48
Mol File:
107615-77-0.mol
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11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA Chemical Properties

solubility 
10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a)
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11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA Usage And Synthesis

Description

11β-13,14-dihydro-15-keto PGF is a metabolite of PGD2 in the 15-hydroxy PGDH pathway.1,2 Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF, as the immediate product, and 11β-13,14-dihydro-15-keto PGF in the plasma within 10 minutes.1 Homogenates of human lung metabolize PGD2 first to 11β-PGF and then to 11β-15-keto-PGF in the presence of NAD+, but not 11β-13,14-dihydro-15-keto PGF.2 Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF, via 11β-PGF, in the presence of NAD+ and NADP+.2

Definition

ChEBI: 11beta-13,14-dihydro-15-keto-PGF2alpha is a prostanoid.

References

1. Robinson, C., Hardy, C.C., and Holgate, S.T. The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men Biochim. Biophys. Acta 963(2),151-161(1988).
2. Robinson, C., Herbert, C.A., Bedwell, S., et al. The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways Biochem. Pharmacol. 38(19),3267-3271(1989).

11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHASupplier

Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
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Hangzhou Synstar pharmaceutical Technology CO.,Ltd
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0571-85361029
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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TargetMol Chemicals Inc.
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15002134094
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marketing@targetmol.cn
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