1-(Ethoxycarbonyl)-β-carboline Chemical Properties

Melting point:

145-146 °C

Boiling point:

470.9±25.0 °C(Predicted)

Density 

1.308±0.06 g/cm3(Predicted)

form 

Solid

pka

14.21±0.40(Predicted)

color 

Light yellow to orange

InChI

InChI=1S/C14H12N2O2/c1-2-18-14(17)13-12-10(7-8-15-13)9-5-3-4-6-11(9)16-12/h3-8,16H,2H2,1H3

InChIKey

CFXOOHNXLDSCHT-UHFFFAOYSA-N

SMILES

N1C2=C(C=CC=C2)C2C=CN=C(C(OCC)=O)C1=2

1-(Ethoxycarbonyl)-β-carboline Usage And Synthesis

Uses

Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC50 = 4.87 μg/mL) and elastase release (IC50 = 6.29 μg/mL)[1].

References

[1] Fang HW, et al. Total synthesis of cordatanine, structural reassignment of drymaritin, and anti-inflammatory activity of synthetic precursors. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3822-4. DOI:10.1016/j.bmcl.2015.07.074