2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-N-2-PROPYNYL-, HYDROCHLORIDE Chemical Properties

Boiling point:

327.4±37.0 °C(Predicted)

Density 

1.03±0.1 g/cm3(Predicted)

pka

7.72±0.20(Predicted)

2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-N-2-PROPYNYL-, HYDROCHLORIDE Usage And Synthesis

Uses

2-PAT, an analogue of Rasagiline and Selegiline, a reversible MAO-A inhibitor with an IC50 of 0.721 μM. 2-PAT is an inactivator of MAO-B with an IC50 of 14.6 μM. 2-PAT has?the?potential?for?Parkinson’s disease and depression?research[1].

IC 50

MAO-A: 0.721 μM (IC₅₀); MAO-B: 14.6 μM (IC₅₀)

References

[1] Letitia Meiring, et al. The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase. Bioorg Med Chem Lett. 2022 Jul 1;67:128746. DOI:10.1016/j.bmcl.2022.128746

2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-N-2-PROPYNYL-, HYDROCHLORIDE(134467-58-6)Related Product Information

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