FURO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID Chemical Properties

Melting point:

>320℃

Boiling point:

353.0±22.0 °C(Predicted)

Density 

1.455

storage temp. 

2-8°C

pka

1.95±0.30(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933399990

FURO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID Usage And Synthesis

Synthesis

General procedure for the synthesis of furo[2,3-c]pyridine-2-carboxylic acid from ethyl furo[2,3-c]pyridine-2-carboxylate: ethyl furo[2,3-c]pyridine-2-carboxylate (3.82 g, 19.98 mmol) was dissolved in a mixed solvent of THF:MeOH (1:1, 6.4 mL) and potassium hydroxide (3.36 g, 59.9 mmol). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the solvent was concentrated under reduced pressure to about 20 mL and the pH was subsequently adjusted with acetic acid to about 4. The precipitated solid product was collected by vacuum filtration, washed twice with water, and dried overnight in a vacuum oven to afford furano[2,3-c]pyridine-2-carboxylic acid (2.90 g, 89% yield). The product was characterized by 1H NMR (DMSO-d6): δ 9.09 (s, 1H), 8.47 (d, 1H), 7.81 (dd, 1H), 7.71 (d, 1H), 3.36 (br s, 1H).

References

[1] Patent: WO2012/31197, 2012, A1. Location in patent: Page/Page column 400-401
[2] Patent: WO2013/127266, 2013, A1. Location in patent: Page/Page column 128; 129; 130
[3] Patent: WO2013/127267, 2013, A1. Location in patent: Page/Page column 79; 81
[4] Patent: WO2013/127269, 2013, A1. Location in patent: Page/Page column 143
[5] Patent: WO2013/127268, 2013, A1. Location in patent: Page/Page column 57; 59

FURO[2,3-C]PYRIDINE-2-CARBOXYLIC ACID(112372-15-3)Related Product Information

• Furo[2,3-b]pyridin-3(2H)-one
• ethyl furo[2,3-c]pyridine-2-carboxylate
• Furo[2,3-c]pyridin-3(2H)-one (9CI)
• furo[2,3-c]pyridin-7-amine
• Furo[3,2-b]pyridine-2-carboxaldehyde (9CI)