Methyl 3-bromoindazole-5-carboxylate Chemical Properties

Boiling point:

399.7±22.0 °C(Predicted)

Density 

1.709

storage temp. 

Store at room temperature

pka

10.62±0.40(Predicted)

Appearance

White to yellow Solid

Safety Information

HS Code 

2933998090

Methyl 3-bromoindazole-5-carboxylate Usage And Synthesis

Synthesis

General procedure for the synthesis of methyl 3-bromo-1H-indazole-5-carboxylate from methyl 1H-indazole-5-carboxylate: a mixture of methyl 1H-indazole-5-carboxylate (1.7 g, 0.01 mol) with N-bromosuccinimide (NBS, 2.1 g, 0.012 mol) in tetrahydrofuran (THF, 10 ml) was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated to give a residue. To the residue was added dichloromethane (DCM, 5 ml), stirred for 30 min and filtered to give methyl 3-bromo-1H-indazole-5-carboxylate (1.9 g, 80% yield) as a light yellow solid.

References

[1] Patent: US2014/128391, 2014, A1. Location in patent: Paragraph 0392; 0393; 0394
[2] Patent: WO2013/78237, 2013, A1. Location in patent: Page/Page column 54

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