Montelukast Dicyclohexylamine Salt
Montelukast Dicyclohexylamine Salt Basic information
- Product Name:
- Montelukast Dicyclohexylamine Salt
- Synonyms:
-
- Montelukast raceMate
- Montelukast Dicyclohexylamine Salt
- 1-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic N-Cyclohexylcyclohexanamine
- Montelukast sodium impurity 8/Montelukast Dicyclohexylamine/1-[1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic N-Cyclohexylcyclohexanamine
- 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt
- Montelukast dicyclohexylamine Impurity
- Montelukast Dicyclohexylamine RS
- Montelukast racemate CRS
- CAS:
- 577953-88-9
- MF:
- C47H59ClN2O3S
- MW:
- 767.51
- EINECS:
- 611-575-8
- Product Categories:
-
- Sulfur & Selenium Compounds
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 577953-88-9.mol
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Montelukast Dicyclohexylamine Salt Chemical Properties
- Melting point:
- 65-67°C
- Density
- 1.2g/cm3 at 20℃
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Pale Beige
- InChIKey
- ZLOLVGQQYDQBMP-UJCKLGLENA-N
- SMILES
- N(C1CCCCC1)C1CCCCC1.C(C1(CC1)CC(=O)O)S[C@@H](C1C=CC=C(/C=C/C2C=CC3=CC=C(Cl)C=C3N=2)C=1)CCC1C=CC=CC=1C(O)(C)C |&1:22,r|
- LogP
- 0.24-4.9 at 20℃
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Montelukast Dicyclohexylamine Salt Usage And Synthesis
Chemical Properties
Pale Beige Solid
Uses
Montelukast Dicyclohexylamine Salt is a selective leukotriene D4-receptor antagonist. Used as an antiasthmatic.
in vivo
Montelukast (3 mg/kg; oral gavage) protects against APAP-induced hepatotoxicity in mice[1].
Montelukast (1 mg/kg; miniosmotic pump administration) reduces the airway remodeling changes observed in OVA-treated mice and blocks the actions of cysteinyl leukotrienes (LT) C4, D4, and E4 mediated by the CysLT1 receptor[2].
Montelukast (1 mg/kg; miniosmotic pump administration) reduces the elevated levels of IL-4 and IL-13 found in the BAL fluid of OVA-treated mice[2].
| Animal Model: | C57BL/6J mice (8-week-old; 22-25 g) are induced acute hepatic injury[1] |
| Dosage: | 3 mg/kg |
| Administration: | Oral gavage 1 h after saline or APAP administration |
| Result: | Decreased serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST), and alleviated liver damage. |
IC 50
CysLT1
Montelukast Dicyclohexylamine SaltSupplier
Shanghai Forever Synthesis Co.,Ltd Gold
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- 18096642264
- sales01@foreversyn.com
J & K SCIENTIFIC LTD.
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- 18210857532; 18210857532
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Nanjing Chemlin Chemical Co., Ltd
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- 025-83697070
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Chemsky（shanghai）International Co.,Ltd.
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- 021-50135380
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Sinopharm Chemical Reagent Co,Ltd.
- Tel
- 86-21-63210123
- sj_scrc@sinopharm.com