5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Chemical Properties

Melting point:

89-90

storage temp. 

2-8°C

solubility 

Soluble in DMSO (>30 mg/ml)

form 

solid

color 

Off-white to pale orange

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

CAS DataBase Reference

218457-67-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2933399990

5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE Usage And Synthesis

Description

CB-103 (218457-67-1) is an orally active inhibitor of the Notch signaling activation complex (IC50’s from 0.9 to 3.9 μM in various cell-based assays), the most downstream level of the Notch signaling pathway. It inhibited the growth of Notch-addicted human T cell acute lymphoblastic leukemia cells as well as other cell lines.? CB-103 also inhibited the growth of human breast cancer and leukemia xenografts without the intestinal toxicity associated with γ-secretase Notch inhibitors.

References

Lehal et al. (2020), Pharmacological disruption of the Notch transcription factor complex; Proc. Natl. Acad. Sci. USA, 117 16292

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