TebipeneM pivoxil (hydrochloride)
TebipeneM pivoxil (hydrochloride) Basic information
- Product Name:
- TebipeneM pivoxil (hydrochloride)
- Synonyms:
-
- TebipeneM pivoxil (hydrochloride)
- ZXGTYOBSVQZXSC-HXLQFWNVSA-N
- CAS:
- 211558-19-9
- MF:
- C22H32ClN3O6S2
- MW:
- 534.08
- Mol File:
- 211558-19-9.mol
TebipeneM pivoxil (hydrochloride) Usage And Synthesis
Uses
Tebipenem pivoxil (L084) hydrochloride is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil hydrochloride binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis[1].
in vivo
Tebipenem pivoxil (L084) (0-4.00 g/kg; p.o.; once) hydrochloride shows minimal lethal dosage (MLD) of 4.00 g/kg and the maximum tolerance dosage (MTD) of 3.40 g/kg in mice[1].
Tebipenem pivoxil (50 and 100 mg/kg; p.o.; once) hydrochloride significantly protects the sepsis mice challenged with various pathogenic bacteria[1].
| Animal Model: | KM mice weighing 18–22 g[1] |
| Dosage: | 2.89, 3.40 and 4.00 g/kg |
| Administration: | Oral administration (tablet), once |
| Result: | Within the 14-day observation period, only one mouse was dead in the maximum oral dosage (4.00 g/kg). The minimal lethal dosage (MLD) was 4.00 g/kg and the maximum tolerance dosage (MTD) in the mice was 3.40 g/kg. Showed dose-dependent liver and kidney damage. |
| Animal Model: | ICR mice, sepsis mouse models[1] |
| Dosage: | 50 and 100 mg/kg |
| Administration: | Oral administration (tablet), once |
| Result: | Significantly increased the survival number of the sepsis mice within a 168 h observation period. |
IC 50
β-lactam
References
[1] Yao Q, et al. Antibacterial Properties of Tebipenem Pivoxil Tablet, a New Oral Carbapenem Preparation against a Variety of Pathogenic Bacteria in Vitro and in Vivo. Molecules. 2016 Jan 6;21(1):62. DOI:10.3390/molecules21010062