1,3-BENZOXAZOL-6-AMINE Chemical Properties

Melting point:

88 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

Solid

color 

Orange to brown

Water Solubility 

Slightly soluble in water.

Sensitive 

Air Sensitive

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-36-22

Safety Statements 

22-26-36/37/39

RIDADR 

2811

HazardClass 

IRRITANT

HS Code 

2934999090

1,3-BENZOXAZOL-6-AMINE Usage And Synthesis

Uses

6-Aminobenzoxazole is used as pharmaceutical intermediate.

Definition

ChEBI: 6-Amino-benzoxazole is a benzoxazole.

Synthesis

GENERAL METHOD: 6-nitro-1,3-benzoxazole (6.13 mmol) was dissolved in ethanol (30 mL) and 10% Pd/C catalyst was added (the amount of catalyst was 20% of the mass of 6-nitro-1,3-benzoxazole). The mixture was placed in a Parr hydrogenation unit and the hydrogenation reaction was carried out at 50 psi H?(g) pressure overnight. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum to remove the solvent. The crude product was purified by fast column chromatography using a 30%-40% ethyl acetate/hexane gradient elution to give pure 6-aminobenzoxazole.

References

[1] ACS Catalysis, 2015, vol. 5, # 3, p. 1526 - 1529
[2] Molecules, 2014, vol. 19, # 1, p. 925 - 939
[3] Collection of Czechoslovak Chemical Communications, 1996, vol. 61, # 2, p. 268 - 275
[4] Collection of Czechoslovak Chemical Communications, 1996, vol. 61, # 3, p. 371 - 380
[5] Chemical Communications, 2011, vol. 47, # 39, p. 10972 - 10974

1,3-BENZOXAZOL-6-AMINE(177492-52-3)Related Product Information

• 2-(4-AMINOPHENYL)-6-AMINOBENZOXAZOLE
• 2-Methyl-6-nitrobenzoxazole
• 6-NITRO BENZOXAZOLINONE
• 5-CHLORO-6-BENZOXAZOLAMINE
• 2-(2-NAPHTHYL)-1,3-BENZOXAZOL-5-AMINE
• 2-Methyl-5-chloro-6-benzoxazolamine
• 1,3-BENZOXAZOL-2-AMINE
• 6-Amino-2-methylbenzoxazole
• Benzoxazole
• Oxazole
• N-METHYL-N'-(2-METHYL-1,3-BENZOXAZOL-6-YL)THIOUREA
• 6-Amino-2-(3-aminophenyl)benzoxazole
• OTAVA-BB 1315014
• 2-(4-METHOXY-PHENYL)-BENZOOXAZOLE-6-YLAMINE
• OTAVA-BB 1315037
• 6-NITRO-1,3-BENZOXAZOLE
• 2-Phenyl-benzooxazol-6-ylamine
• 5-CHLORO-2-METHYL-6-NITRO-1,3-BENZOXAZOLE