Simeprevir sodium Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO:30.0(Max Conc. mg/mL);38.86(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.43(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);38.86(Max Conc. mM)

form 

A crystalline solid

Simeprevir sodium Usage And Synthesis

Description

Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (K_i = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC₅₀ value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.

Simeprevir sodium(1241946-89-3)Related Product Information

• Simeprevir