pyrazolo[1,5-a]pyrazine Chemical Properties

Density 

1.29±0.1 g/cm3(Predicted)

pka

0.33±0.30(Predicted)

pyrazolo[1,5-a]pyrazine Usage And Synthesis

Synthesis

A four-step protocol for the synthesis of pyrazolo[1,5-a]pyrazines has been reported by Peter J. Lindsay-Scott and colleagues[1]. Commercially available pyrazoles were alkylated and formylated in a regiocontrolled manner to give pyrazole-5-aldehydes bearing 2,2-dialkoxyethyl substitution on N-1. Efficient conditions for the subsequent deprotection and cyclization of these intermediates allowed access to pyrazolo[1,5-a]pyrazines with multiple substitution patterns.

References

[1] A Flexible Strategy for the Regiocontrolled Synthesis of Pyrazolo[1,5-a]pyrazines. J. Org. Chem. 2017, 82, 20, 11295–11303. DOI: 10.1021/acs.joc.7b02128

pyrazolo[1,5-a]pyrazine(24973-85-1)Related Product Information

• Pyrazolo[1,5-a]pyriMidin-7-ol
• Pyrazolo[1,5-a]pyridin-3-amine, hydrochloride (1:1)
• pyrazolo[1,5-a]pyrazine-3-carboxylic acid
• ETHYL PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLATE
• Pyrazolo[1,5-a]pyridine-3-carboxylic acid
• 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE
• Pyrazolo[1,5-a]pyrazin-3-amine
• Pyrazolo[1,5-a]pyridine-5-methanol
• 7-CHLORO-3-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE
• pyrazolo[1,5-a]pyridin-5-ylMethanol
• PYRAZOLO[1,5-A]PYRIDIN-3-YLAMINE
• Pyrazolo[1,5-a]pyridine, 5-(chloromethyl)-
• ethyl pyrazolo[1,5-a]pyrazine-3-carboxylate
• PYRAZOLO[1,5-A]PYRIDIN-3-YLAMINE HYDROCHLORIDE