Cefiderocol Chemical Properties

storage temp. 

Store at -20°C, stored under nitrogen,unstable in solution, ready to use.

solubility 

DMSO:50.0(Max Conc. mg/mL);66.47(Max Conc. mM)

form 

Solid

color 

White to off-white

InChIKey

DBPPRLRVDVJOCL-OLKYWZQRNA-N

SMILES

C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC(C)(C)C(=O)O)C(=O)N12)C[N+]1(CCCC1)CCNC(C1C=CC(O)=C(O)C=1Cl)=O)(=O)[O-] |&1:5,7,r|

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Cefiderocol Usage And Synthesis

Uses

Cefiderocol, is a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, that has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species,

reaction suitability

reagent type: chelator

Pharmaceutical Applications

Cefiderocol can be used for the treatment of complicated urinary tract infections (cUTIs) when other treatment options are limited or nonexistent.

Biological Activity

Mode of Action:  Cefiderocol binds to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding affinity inhibits the synthesis of the bacterial cell wall, leading to cell lysis and bacterial death.

Antimicrobial Spectrum: Cefiderocol has strong antimicrobial properties, especially against a wide spectrum of Gram-negative pathogens. Due to its siderophore core it is also a natural iron-chelator, which adds to its antibacterial activities.

Synthesis

Below shows the synthesis route of Cefiderocol

IC 50

β-lactam

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