Basic information Safety Supplier Related

5'-O-DMTr-N6-Fmoc-dA-phosphoramidite

Basic information Safety Supplier Related

5'-O-DMTr-N6-Fmoc-dA-phosphoramidite Basic information

Product Name:
5'-O-DMTr-N6-Fmoc-dA-phosphoramidite
Synonyms:
  • 5'-O-DMTr-N6-Fmoc-dA-phosphoramidite
  • Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 2'-Deoxy-5'-O-DMT-N6-Fmoc-adenosine 3'CE-phosphoramidite
  • 5’-O-DMTr-N6-Fmoc-dA-phosphoramidite
CAS:
109420-86-2
MF:
C55H58N7O8P
MW:
976.06
Mol File:
109420-86-2.mol
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5'-O-DMTr-N6-Fmoc-dA-phosphoramidite Usage And Synthesis

Uses

2'-Deoxy-5'-O-DMT-N6-Fmoc-adenosine 3'CE-phosphoramidite is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

References

[1] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020

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