4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-
4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl- Basic information
- Product Name:
- 4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-
- Synonyms:
-
- 4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-
- Sigma-LIGAND-1
- SigmaLIGAND1,Sigma LIGAND 1
- Sigma-LIGAND-1, 10 mM in DMSO
- CAS:
- 139652-01-0
- MF:
- C27H33NO4
- MW:
- 435.55522
- Mol File:
- 139652-01-0.mol
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4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl- Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
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4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl- Usage And Synthesis
Uses
Sigma-LIGAND-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000 nM at the dopamine D2 receptor[1].
in vivo
Administration of Sigma-LIGAND-1 would reverse amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 and its structural analogues have the potential antipsychotic activity[1].
References
[1] Erickson RH, et al. (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem. 1992 May 1;35(9):1526-35. DOI:10.1021/jm00087a005
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