L-Leucine, N-[4-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl]amino]-1-piperidinyl]benzoyl]- Chemical Properties

Melting point:

>177 °C (decomp)

Density 

1.37±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

3.78±0.10(Predicted)

L-Leucine, N-[4-[4-[[(2R)-2-hydroxy-2-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethyl]amino]-1-piperidinyl]benzoyl]- Usage And Synthesis

Description

β3-AR agonist 2 is a potent and selective β3-adrenergic receptor (β3-AR) agonist with an EC50 of 8 nM.

β3-AR agonist 2 (Compound 26e) is found to be potent and selective at the β3 receptor, nearly completely abolishes intrinsic activity at either the β1 or β2 receptor[1].

β3-AR agonist 2 (Compound 26e) has significant thermogenesis effects on human β3-adrenergic receptor transgenic mice. β3-AR agonist 2 acts as a potential drug for the treatment of human obesity and type II diabetes[1].

References

[1]. Hu B, et al. (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists. J Med Chem. 2001 Apr 26;44(9):1456-66.