1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE
1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Basic information
- Product Name:
- 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE
- Synonyms:
-
- RS 67506 HYDROCHLORIDE
- 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE
- 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
- N-[2-[4-[3-(4-amino-5-chloro-2-methoxyphenyl)-3-oxopropyl]piperidin-1-yl]ethyl]methanesulfonamide
- N-(2-(4-(3-(4-Amino-5-chloro-2-methoxyphenyl)-3-oxopropyl)piperidin-1-yl)ethyl)methanesulfonamide hydrochloride
- 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(1-2-methylsulfonylamino)ethyl-4-piperidinyl)-1-propanonehydrochloride
- RS67506HCl
- RS 67506
- CAS:
- 168986-61-6
- MF:
- C18H29Cl2N3O4S
- MW:
- 454.41
- Mol File:
- 168986-61-6.mol
1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Chemical Properties
- storage temp.
- Store at RT
- solubility
- Soluble to 80 mM in H2O
- form
- Powder
- Water Solubility
- Soluble to 80 mM in water
1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Usage And Synthesis
Uses
RS 67506 Hydrochloride is a novel and potent 5-HT4 receptor agonist.
Definition
ChEBI: A hydrochloride salt obtained by mixing equimolar amounts of RS 39604 with hydrochloric acid. A potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and alpha1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
Biological Activity
A potent and selective 5-HT 4 partial agonist, with a pK i of 8.8 at 5-HT 4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT 1A, 1D, 2A, 2C , D 1 , D 2 and M 1-3 . It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.
in vitro
rs 67506 acted as a potent partial agonist with respect to 5-ht at the 5-ht4 receptor regulating relaxation of the carbachol-precontracted oesophagus. relaxant responses to rs 67506 was surmountably antagonized with apparent affinities (pkb) of 9.0. rs 67506, therefore, acted as potent, partial 5-ht4 receptor agonists in vitro. the compound may have been used in elucidating the physiological role in 5-ht4 receptors by virtue of their high potency and selectivity [1].
in vivo
rs 67506 induced dose-dependent potentiates heart rate of the anaesthetized micropig (ed50 5.4 pg kg-1, i.v.) with maximal increases of 47 beats min-1 [1]. in addition, in a rat model of spatial learning and memory, the effects of two novel potent and selective 5-ht4 receptor agonists (rs67333 and rs67506) were studied. by contrast, there was no effect seen to rs67506 (0.1, 10 and 1000 pg/kg, i.p.) of equivalent potency and selectivity to rs67333.this differential result may suggest the enhanced ability of rs67333 to enter the cns, with respect to rs67506 [2].
References
[1]. eglen rm, bonhaus dw, johnson lg, leung e, clark rd. pharmacological characterization of two novel and potent 5-ht4 receptor agonists, rs 67333 and rs 67506, in vitro and in vivo. br j pharmacol. 1995 aug;115(8):1387-92.
[2]. fontana dj, daniels se, wong eh, clark rd, eglen rm. the effects of novel, selective 5-hydroxytryptamine (5-ht) 4 receptor ligands in rat spatial navigation. neuropharmacology. 1997 apr-may;36(4-5):689-96.
1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDESupplier
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Tel
- 888-539-0666
- info@emmx.com
- Tel
- 15921286451; 15921286451
- 2010681527@qq.com
- Tel
- 0513-66337626 18051384581
- sales@chemhifuture.com
1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE(168986-61-6)Related Product Information
- 4-aminohexanoylphenone
- 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE
- 1-[4-AMINO-5-CHLORO-2-(3,5-DIMETHOXYPHENYL)METHYLOXY]-3-[[1-[2-METHYLSULPHONYLAMINO]ETHYL]PIPERIDIN-4-YL]PROPAN-1-ONE HYDROCHLORIDE
- 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[(1-2-METHYLSULPHONYLAMINO)ETHYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE
- 2-Chloro-5-methoxyaniline
- 1-(4-Amino-2-hydroxy-phenyl)-propan-1-one
- 1-(4-AMINO-3-CHLORO-PHENYL)-PROPAN-1-ONE
- P-HEXYLANILINE HYDROCHLORIDE
- 4-(3-PHENYL-PROPYL)-PIPERIDINE HCL