Acetamide, N-[[(5S)-3-[3-fluoro-4-(1-oxido-4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]- Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO : 100 mg/mL (270.70 mM; Need ultrasonic)

form 

Solid

color 

White to off-white

Acetamide, N-[[(5S)-3-[3-fluoro-4-(1-oxido-4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]- Usage And Synthesis

Uses

PNU-101603 is a sulfoxide metabolite of Sutezolid.html" class="link-product" target="_blank">Sutezolid (HY-10392). PNU-101603 alone or combined with SQ109.html" class="link-product" target="_blank">SQ109 (HY-14989) shows excellent activity against Mycobacterium tuberculosis (MTB), as well as against agent-susceptible and multidrug-resistant TB[1][2].

References

[1] Reddy VM, et al. SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro. J Antimicrob Chemother. 2012 May;67(5):1163-6. DOI:10.1093/jac/dkr589
[2] Barbachyn MR, et al. Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity. J Med Chem. 1996 Feb 2;39(3):680-5. DOI:10.1021/jm950956y