(S)-2-(6,7-DIHYDRO-5H-THIAZOLO[4,5-F]INDOL-2-YL)-4,5-DIHYDROTHIAZOLE-4-CARBOXYLIC ACID
(S)-2-(6,7-DIHYDRO-5H-THIAZOLO[4,5-F]INDOL-2-YL)-4,5-DIHYDROTHIAZOLE-4-CARBOXYLIC ACID Basic information
- Product Name:
- (S)-2-(6,7-DIHYDRO-5H-THIAZOLO[4,5-F]INDOL-2-YL)-4,5-DIHYDROTHIAZOLE-4-CARBOXYLIC ACID
- Synonyms:
-
- (S)-2-(6,7-DIHYDRO-5H-THIAZOLO[4,5-F]INDOL-2-YL)-4,5-DIHYDROTHIAZOLE-4-CARBOXYLIC ACID
- Cyluc1 [(4S)-2-(6,7-Dihydro-5H-thiazolo[4,5-f]indol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid]
- CycLuc1(Luciferase substrate)
- CYCLUC1
- Luciferase substrate
- 4-Thiazolecarboxylic acid, 2-(6,7-dihydro-5H-pyrrolo[3,2-f]benzothiazol-2-yl)-4,5-dihydro-, (4S)-
- CycLuc1 (R)-2-(6,7-dihydro-5H-thiazolo[4,5-f]indol-2-yl)-4,5-dihydrothiazole- 4-carboxylic acid
- CycLuc 1,inhibit,CycLuc1,Reactive Oxygen Species,Inhibitor,CycLuc-1
- CAS:
- 1247879-16-8
- MF:
- C13H11N3O2S2
- MW:
- 305.38
- Mol File:
- 1247879-16-8.mol
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(S)-2-(6,7-DIHYDRO-5H-THIAZOLO[4,5-F]INDOL-2-YL)-4,5-DIHYDROTHIAZOLE-4-CARBOXYLIC ACID Chemical Properties
- Boiling point:
- 606.8±65.0 °C(Predicted)
- Density
- 1.84±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 83.33 mg/mL (272.87 mM)
- pka
- 3.54±0.20(Predicted)
- form
- Solid
- color
- Yellow to brown
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(S)-2-(6,7-DIHYDRO-5H-THIAZOLO[4,5-F]INDOL-2-YL)-4,5-DIHYDROTHIAZOLE-4-CARBOXYLIC ACID Usage And Synthesis
Uses
Luciferase Substrate, CycLuc1 has been used for transfecting HEK293 cells to study the inhibition of intracellular luciferase crystallization by D-luciferin and its synthetic analogues.
Biological Activity
Cell permeable: yes', 'Primary Target
Luciferase
in vivo
CycLuc1 (0.05-5 mM, intraperitoneally injected) can improve bioluminescence imaging (BLI) of the existing luciferase reporter protein in mice and achieve brain imaging that D-luciferin cannot achieve[2].
| Animal Model: | Mouse xenograft tumor models[2] |
| Dosage: | 0.05, 0.5, 1, 5 mM, 100 μL |
| Administration: | i.p. |
| Result: | Yielded a >10-fold higher bioluminescent signal than could be obtained from D-luciferin injection at equivalent doses. |
storage
Store at -20°C
(S)-2-(6,7-DIHYDRO-5H-THIAZOLO[4,5-F]INDOL-2-YL)-4,5-DIHYDROTHIAZOLE-4-CARBOXYLIC ACIDSupplier
Guangzhou Biolight Biotechnology Co., Ltd. Gold
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- 400-856 2998 13268301529
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Beijing Ouhe Technology Co., Ltd
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- 010-010-82967028 13522913783
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Shanghai Topbiochem Technology Co., Ltd
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- 021-58170097
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Nanjing Dulai Biotechnology Co., Ltd.
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266