endo-BCN-PEG2-acid Chemical Properties

Boiling point:

546.4±40.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

storage temp. 

-20°C, sealed storage, away from moisture

solubility 

Soluble in DMSO, DCM, DMF

form 

Liquid

pka

4.28±0.10(Predicted)

color 

Colorless to light yellow

endo-BCN-PEG2-acid Usage And Synthesis

Description

endo-BCN-PEG2-acid is a PEG linker containing a BCN group and a terminal carboxylic acid. The BCN group can react with azide-tagged biomolecules. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

endo-BCN-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. endo-BCN-PEG2-acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Sano K, et al. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. DOI:10.1021/bc400050k