[2-[(2-chloro-6-methylaminopurin-9-yl)methyl]-3-phosphonopropyl]phosphonic acid Chemical Properties

Boiling point:

741.3±70.0 °C(Predicted)

Density 

2.00±0.1 g/cm3(Predicted)

pka

1.91±0.10(Predicted)

[2-[(2-chloro-6-methylaminopurin-9-yl)methyl]-3-phosphonopropyl]phosphonic acid Usage And Synthesis

Description

MRS2496 is a P2Y(1) receptor antagonist. It is less potent than MRS2500.

Uses

MRS2496 is a selective P2Y1 receptor antagonist with an IC50 value of 1.5 μM, exhibiting antiplatelet aggregation activity. MRS2496 can be used in the research of antiplatelet aggregation and blood-related diseases[1].

IC 50

P2Y1 Receptor

References

[1] Cattaneo M, et al. Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochem Pharmacol. 2004 Nov 15;68(10):1995-2002. doi: 10.1016/j.bcp.2004.06.026. DOI:10.1016/j.bcp.2004.06.026