Basic information Safety Supplier Related

TETRAGASTRIN

Basic information Safety Supplier Related

TETRAGASTRIN Basic information

Product Name:
TETRAGASTRIN
Synonyms:
  • (3S)-3-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-phenylmethoxycarbonylamino-propanoyl]amino]-4-methylsulfanyl-butanoyl]amino]propanoic acid
  • 4-7-Cholecystokinin-7 (swine) (9CI)
  • Alaninamide, L-tryptophyl-L-methionyl-L-aspartylphenyl- (7CI)
  • Alaninamide, L-tryptophyl-L-methionyl-L-aspartylphenyl-, L- (8CI)
  • Cholecystokinin C-terminal tetrapeptide
  • Cholecystokinin(36-39)
  • L-Phenylalaninamide, L-tryptophyl-L-methionyl-L-a-aspartyl-
  • Cholecystokinin fragment 30-33 amide
CAS:
1947-37-1
MF:
C29H36N6O6S
MW:
596.7
Mol File:
1947-37-1.mol
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TETRAGASTRIN Chemical Properties

Melting point:
185-195 °C
Boiling point:
1070.0±65.0 °C(Predicted)
Density 
1.348±0.06 g/cm3(Predicted)
storage temp. 
-20°C
form 
Solid
pka
4.19±0.10(Predicted)
color 
White to off-white
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Safety Information

WGK Germany 
3
Toxicity
dog,LD,intravenous,> 100mg/kg (100mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: EXCITEMENT,Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 121, 1969.
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TETRAGASTRIN Usage And Synthesis

Uses

Cholecystokinin Fragment 30-33 Amide can be used for inactivating the CCK8 antiserum. The product can also be used as an antigen utilized in absorption control for testing the specificity of antisera.

Definition

ChEBI: Tetragastrin is a tetrapeptide composed of L-tryptophan, L-methione, L-aspartic acid and L-phenylalaninamide residues joined in sequence. It has a role as an anxiogenic and a human metabolite. It is a tetrapeptide and a peptidyl amide.

Hazard

Moderately toxic by ingestion

Biochem/physiol Actions

Cholecystokinin Fragment 30-33 Amide also referred to as CCK-4 or Trp-Met-Asp-Phe amide is a peptide fragment derived from peptide hormone cholecystokinin. CCK-4 is a panicogenic agent that induces panic attacks in humans. This property of the compound can be used in scientific research for testing the new anxiolytic drugs.

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