NERVONIC CERAMIDE Chemical Properties

Melting point:

80-82°C

storage temp. 

-20°C

solubility 

Chloroform (Slightly), Methanol (Slightly, Heated)

form 

Solid

color 

Off-White

NERVONIC CERAMIDE Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

N-Nervonoyl-D-sphingosine is a sphingolipid. Sphingolipids (SLs) act as signaling molecules and as structural components in both neuronal cells and myelin.

Uses

Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of phospholipase C, appropriately named sphingomyelinase.

Definition

ChEBI: N-(15Z)-tetracosenoylsphingosine is an N-tetracosenoylsphingosine in which the double bond in the ceramide acyl group is located at position 15 (the Z-geoisomer. It has a role as a mouse metabolite. It is a N-tetracosenoylsphingosine and a Cer(d42:2). It is functionally related to a (15Z)-tetracosenoic acid.

Biological Activity

Ceramide (d18:1/24:1[15Z]) levels are elevated inprimary open angle glaucoma (POAG). It is a biomarker for the human arterial tissue and plasma major adverse cardiac and cerebrovascular events (MACE). In general, ceramides are key second messengers in sphingomyelin pathway and modulate the pathophysiology of metabolic diseases.

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